Potential associations of food allergy and altered neurodevelopment in children

Introduction Allergic immune reactions and adverse to foods, have been described as having growth concerns in children with food allergy. Moreover, dysregulation inflammation documented typical hallmarks both allergic neurodevelopmental conditions. Objectives In this review, we address the association of allergy altered neurodevelopment children. Methods We comprehensively review scientific literature using Pubmed database other search platforms state potential associations Results Food is a pathological, potentially deadly, reaction activated by normally inoffensive protein antigens. It an important public health problem that affects (children under age 5 years: %) adults, it has increasing prevalence last 2 3 decades. The enhancement knowledge pathophysiological mechanisms lead many suggestions such role intestinal microbiota, immunological adaptation mucosal system antigens nutritional impact recent studies reviews, significant positive common conditions, particular allergy, autism spectrum disorder attention deficit hyperactivity disorders reported. At mechanistic level, was recently shown through animal models, intracranial Mast cells neuroinflammation neuropathology associated well dysfunction gut-brain axis promoting white matter development during early life when brain vulnerable environment (such restrictions) can result wide later life. also enhanced mTOR signaling gut, which may behavioral development. Conclusions Neurodevelopmental occur childhood context challenging need more human research understand underlying promote therapeutic innovations. Disclosure Interest None Declared